Lichen simplex chronicus begins as itchy skin. The itching leads to scratching and rubbing, which causes thickening of skin. The thickened skin is itchy, which causes more scratching and, thus, more skin thickening. This scratch-itch cycle continues if not treated.
Conditions that can lead to lichen simplex chronicus include:
- Insect bites
- Eczema (atopic dermatitis)
- Dry skin (xerosis)
- Poor circulation in legs (venous insufficiency)
- Anxiety and stress
- Inner wrists, forearms, and elbows
- Sides and back of neck
- Upper thighs, knees, shins, ankles, and tops of feet
- Vulva, scrotum, anus (anogenital areas)
Individuals with lichen simplex chronicus report periodic itching that is most intense at night or any time they are still.
- The primary treatment is to stop scratching. However, this can be very difficult once a scratch-itch cycle has started. Areas of lichen simplex chronicus may need to be covered at night, as many people scratch in their sleep.
- Use moisturizers to help relieve itchy skin. When choosing a moisturizer, look for oil-based creams and ointments, which work better than water-based lotions. Apply moisturizers just after bathing, while the skin is still moist.
- Apply over-the-counter hydrocortisone cream to decrease the itch. However, if the itching is limited to the groin area, you may have a fungal infection (jock itch [tinea cruris]) rather than lichen simplex chronicus. Do not apply hydrocortisone to the groin area unless recommended to do so by a doctor.
- If there are breaks or cracks in the skin, apply an antibiotic ointment to prevent infection.
- Numbing the skin with an injectable anesthetic.
- Sampling a small piece of skin by using a flexible razor blade, a scalpel, or a tiny cookie cutter (called a "punch biopsy"). If a punch biopsy is taken, a suture or two may be placed and will need to be removed 6–14 days later.
- Having the skin sample examined under the microscope by a specially trained physician (dermatopathologist).
- Aggressive moisturizing techniques
- Corticosteroid (cortisone) creams or ointments
- Creams containing salicylic acid or urea, to improve penetration of the topical corticosteroid
- Oral anti-histamines, especially for use at bedtime
- Injection of corticosteroid solution directly into the lichen simplex chronicus lesions
- Ultraviolet light therapy
- Sedatives or anti-depressants for people with lichen simplex chronicus strongly related to psychological stress
- Doxepin or capsaicin cream
- Topical or oral antibiotics if infection is present