Typical to Raynaud's disease, this image displays purple toes due to constricted blood vessels. Raynaud's disease, or Raynaud's phenomena, refers to abnormal constriction of blood vessels due to cold, causing a blue and white color change of the affected extremity.  This image displays the blue color of the fingers typical of Raynaud's disease due to the constriction of blood vessels. This image displays white toes from constriction of the skin's blood vessels. This image displays fingers that are purple and chronically cold due to Raynaud's disease. This image displays the hands of a person with scleroderma and a severe case of Raynaud's disease.
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Raynaud's Phenomenon  Information for adults

Picture of Raynaud's Phenomenon: Typical to Raynaud's disease, this image displays purple toes due to constricted blood vessels. Divider line
Typical to Raynaud's disease, this image displays purple toes due to constricted blood vessels.
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Raynaud's phenomenon is a disorder in which the blood vessels to the fingers and toes (digits) become abnormally closed off (constricted). The fingers and toes of individuals with Raynaud's phenomenon change color from white to blue to red, often causing them to feel numb. Raynaud's phenomenon is sometimes seen with autoimmune diseases, such as rheumatoid arthritis, scleroderma, and lupus, where the body's immune system turns against itself, causing various symptoms. Other causes of Raynaud's phenomenon include repeated trauma/vibration, abnormalities in the structure of blood vessels, and drug injection into one type of blood vessel (arteries).
Who's At Risk
Raynaud's phenomenon usually affects younger to middle-aged women. When it affects men, it is usually seen in middle age or later in life. Raynaud's phenomenon is seen in 20% of people with lupus.
Signs and Symptoms
  • Raynaud's phenomenon affects the fingers and toes (digits). The digits feel cool and their color changes from white to blue to red.
  • Severe Raynaud's phenomenon can result in skin ulcers. This complication is more common in people who have both scleroderma and Raynaud's phenomenon.
  • People with Raynaud's phenomenon may have more noticeable small blood vessels (capillaries) into their fingers and toes where the nail plate meets the skin of the finger (proximal nail fold), particularly in people who also have an autoimmune disease.
Self-Care Guidelines
Avoid exposure to cold as much as possible, and do not smoke, as this contributes to blood vessel narrowing.
When to Seek Medical Care
See your doctor if you notice symptoms suspicious for Raynaud's phenomenon. Further testing may be needed to see if you might have another medical condition that is causing your symptoms.
Treatments Your Physician May Prescribe
  • Oral medications, including nifedipine (a blood pressure medication), epoprostenol (a prostaglandin), or a drug that affects the nerves (selective serotonin reuptake inhibitor), such as fluoxetine.
  • Topical nitroglycerin paste, which helps to dilate blood vessels, may be used as needed to treat or prevent active Raynaud's phenomenon. Apply the paste carefully as it can lead to low blood pressure (hypotension) if used on large areas.
  • Biofeedback, which is a treatment technique in which people are trained to improve their health by using signals from their own bodies, is another therapy for Raynaud's phenomenon.


Bolognia, Jean L., ed. Dermatology, pp.262, 626. New York: Mosby, 2003.

Freedberg, Irwin M., ed. Fitzpatrick's Dermatology in General Medicine. 6th ed. pp.1031, 1326, 1637. New York: McGraw-Hill, 2003.
Last Updated: 15 Mar 2010