Cryosurgery 

There is no preparation needed. Rarely, patients who are very sensitive to pain may apply numbing cream for 30–90 minutes before treatment.

One of the major advantages of this simple, low-risk procedure is that it can be used at any time during a visit to a doctor. For small lesions, liquid nitrogen can be applied using a cotton-tipped applicator, metal probe, or with a spray in fewer than 30 seconds. Larger lesions may require longer freezing cycles lasting 30–60 seconds. Because liquid nitrogen is extremely cold, the treated area turns white from frost. Most patients experience temporary pain during the treatment, with a minor throbbing sensation after the procedure.