Grouped, crusted blisters on the lips and chin are typical of herpes simplex infection. This image displays a blister with a central depression, typical of herpes simplex. The first time a person contracts a herpes infection, there is often severe blistering, pain, and sometimes fever. This image displays an unusual area for the herpes simplex infection. This image displays a mucosal blister caused by a herpes simplex infection. This image displays a herpes simplex infection on the face. This image displays early crusting and swelling typical of recurrent herpes. This image displays multiple grouped herpes lesions that are starting to crust and dry. Small blisters are early typical lesions of herpes simplex infection. Lip blisters of herpes simplex infection can often have a yellow or gray color.
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Cold Sores (Orofacial Herpes)  Teen information

Picture of Cold Sores (Orofacial Herpes): Grouped, crusted blisters on the lips and chin are typical of herpes simplex infection. Divider line
Grouped, crusted blisters on the lips and chin are typical of herpes simplex infection.
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Signs and Symptoms
The most common locations for HSV-1 infections include:
  • Lips
  • Mouth (including gums, tongue, roof of mouth, and inside the cheeks)
  • Nose
  • Chin
  • Cheeks
Shortly after exposure to the virus, a newly infected person may develop fluid-filled blisters, occurring singly or in a cluster. These blisters may be yellow to gray and are fragile, so that many people never notice blisters but instead see tiny ulcers. These ulcers subsequently become scabbed over and may appear dry and yellow. The scabs eventually fall off, leaving a red area that fades. The first (primary) HSV outbreak typically lasts 1–3 weeks.

In mild cases of primary orofacial HSV infection, an individual may develop 1 or 2 cold sores, or the newly infected person may notice no symptoms at all. The lymph nodes in the neck may or may not be swollen. In severe cases of HSV infections, the infection may involve the entire lining of the mouth and both lips. These severe HSV infections may be accompanied by fever, sore throat, foul breath, and difficulty eating.

Repeat (recurrent) HSV infections are often milder than the primary infection, though they look alike. However, some people never develop the symptoms of a primary HSV infection and may mistake a recurrent infection for a primary infection. A recurrent infection typically lasts 7–10 days. People who are prone to recurrent outbreaks tend to get them 3–4 times per year.

Many people with recurrent HSV infections report that the skin lesions are preceded by sensations of burning, itching, or tingling (prodrome). About 24 hours after the prodrome symptoms begin, the actual lesions appear as one or more small blisters or open sores, which eventually become scabbed over.

Triggers of recurrent HSV infections include:
  • Fever or illness
  • Sun exposure
  • Hormonal changes, such as those due to menstruation or pregnancy
  • Stress
  • Injury, such as that caused by dental work or cuts from shaving
  • Surgery
Last Modified: 22 Dec 2008