Grouped, crusted blisters on the lips and chin are typical of herpes simplex infection. This image displays a blister with a central depression, typical of herpes simplex. The first time a person contracts a herpes infection, there is often severe blistering, pain, and sometimes fever. This image displays an unusual area for the herpes simplex infection. This image displays a mucosal blister caused by a herpes simplex infection. This image displays a herpes simplex infection on the face. This image displays early crusting and swelling typical of recurrent herpes. This image displays multiple grouped herpes lesions that are starting to crust and dry. Small blisters are early typical lesions of herpes simplex infection. Lip blisters of herpes simplex infection can often have a yellow or gray color.
Share |

Cold Sores (Orofacial Herpes)  Teen information

Picture of Cold Sores (Orofacial Herpes): Grouped, crusted blisters on the lips and chin are typical of herpes simplex infection. Divider line
Grouped, crusted blisters on the lips and chin are typical of herpes simplex infection.
left arrow
right arrow
Treatments Your Provider May Prescribe
Most HSV infections are easy for physicians to diagnose. On occasion, however, a swab from the infected skin may be sent to the laboratory for viral culture, which takes a few days to grow. Blood tests may also be performed.

Untreated HSV infections will go away on their own, but medications can reduce the symptoms and shorten the duration of outbreaks. There is no cure for HSV infection.

Treatment for primary HSV infection includes the following oral antiviral medications:
  • Acyclovir pills
  • Valacyclovir pills
  • Famciclovir pills
These medications are usually taken for 5–14 days.

More severe primary HSV infections may require additional medications:
  • Oral antibiotic pills if the areas are also infected with bacteria
  • Topical anesthetic, such as viscous lidocaine, if the areas inside the mouth are very painful
In addition, very severe infections may require intravenous fluids (and even intravenous antiviral medications) or painkillers if the pain prevents you from drinking fluids.

Treatment for recurrent HSV infection includes the same oral antiviral medications:
  • Acyclovir pills
  • Valacyclovir pills
  • Famciclovir pills
People who experience early signs (prodromes) before recurrent infections may benefit from episodic treatment, by starting to take medication after the onset of tingling and burning but before the appearance of blisters and sores.

Other people have recurrent infections that are frequent enough or severe enough to justify suppressive therapy, in which medications are taken every day in order to decrease the frequency and severity of attacks.


Last Modified: 22 Dec 2008